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A rat Satb1 truncation causes neurodevelopmental abnormalities recapitulating the symptoms of patients with SATB1 mutations

Hu Zhi-bin, Liu Wei-tang, Li Yi-wei, Hu Ling, Huang Ying, Liu Xi-yue, Zhang Qiong, Wang Yu-bing, Chen Jia-yin, Li Ze-xuan, Tu Si-xin, Zhao Li, Song Ning-ning, Klavir Oded, Ding Yu-qiang

期刊: ACTA PHARMACOLOGICA SINICA | 发表时间: 2025-06-26 | DOI: 10.1038/s41401-025-01588-6 | 影响因子: 8.4

研究领域: 神经生物学, 遗传学, 发育生物学, 药理学, 生物信息学

The inhibitory effects of Cucurbitacin B on hypopharyngeal cancer cell malignant behaviors were investigated based on network pharmacology and molecular docking

Xinjing Liu, Xiang Liu, Tong Qiao, Jing Lei, Man Wang

期刊: Letters in Drug Design & Discovery | 发表时间: 2025-06-17 | DOI: 10.1016/j.lddd.2025.100066 | 影响因子: 1.6

研究领域: 肿瘤学, 药理学, 生物信息学

Disruption of KLHL37-N-Myc complex restores N-Myc degradation and arrests neuroblastoma growth in mouse models

Senfeng Xiang, Pengfei Chen, Xiaoxian Shi, Hanqi Cai, Zihan Shen, Luyang Liu, Aixiao Xu, Jianhua Zhang, Xingya Zhang, Shaowei Bing, Jinhu Wang, Xuejing Shao, Ji Cao, Bo Yang, Qiaojun He, Meidan Ying

期刊: JOURNAL OF CLINICAL INVESTIGATION | 发表时间: 2025-06-10 | DOI: 10.1172/JCI176655 | 影响因子: 13.6

研究领域: 肿瘤学, 分子生物学, 药理学

Berberine protects pancreatic β-cells from IL-1β damage through hormetic mechanisms via p53-mediated apoptosis pathways

Yang Xinyu, Liang Shuntao, Huang Mingyue, Yue Shijun, Jiang Dechun, Yan Dan

期刊: ENDOCRINOLOGY | 发表时间: 2025-06-09 | DOI: 10.1210/endocr/bqaf105 | 影响因子: 3.3

研究领域: 药理学, 内分泌学, 糖尿病研究

Zinc sulfate improves insulin resistance, oxidative stress and apoptosis in liver tissues of PCOS rats through the NF-κB pathway

Yi-fan Kang, Jia-yi Zhao, Jian-rong Liu

期刊: Frontiers in Endocrinology | 发表时间: 2025-06-06 | DOI: 10.3389/fendo.2025.1569866 | 影响因子: 4.6

研究领域: 内分泌学, 分子生物学, 药理学

Clofoctol impairs the stemness of gastric cancer and induces TNF-mediated necroptosis by directly binding to RanBP2

Liu Yi, Ma Yanhui, Zhou Bingqian, Bian Bingxian, Zhou Yunlan, Chen Shiyu, Zhang Peng, Shen Lisong, Chen Hui

期刊: CELLULAR AND MOLECULAR LIFE SCIENCES | 发表时间: 2025-05-06 | DOI: 10.1007/s00018-025-05723-8 | 影响因子: 6.2

研究领域: 肿瘤学, 分子生物学, 药理学

Chidamide, a Histone Deacetylase Inhibitor, Combined With R‐GemOx in Relapsed/Refractory Diffuse Large B‐Cell Lymphoma (TRUST): A Multicenter, Single‐Arm, Phase 2 Trial

Qihua Zou, Yuchen Zhang, Hui Zhou, Yulin Lai, Yi Cao, Zhiming Li, Ning Su, Wenyu Li, Huiqiang Huang, Panpan Liu, Xu Ye, Yudan Wu, Huo Tan, Runhui Zheng, Bingyi Wu, Hui Yang, Liye Zhong, Yuhong Lu, Yang Liang, Peng Sun, Lirong Li, Yingxian Liu, Danling Dai, Yi Xia, Qingqing Cai

期刊: Cancer Medicine | 发表时间: 2025-05-02 | DOI: 10.1002/cam4.70919 | 影响因子: 3.1

研究领域: 肿瘤学, 血液学, 药理学

Self-Adaptive Dynamic Hydrogel Disrupts Ironclad Defense to Augment Photothermal-Catalytic Therapy Against Melanoma Recurrence and Promote Post-Surgical Wound Healing

Hai Zhu, Xinhao Peng, Yanzhuo Liu, Xiaoxian Zhang, Xuequan Zhang, Tinghua Li, Hongmei Liu, Songyue Yang, Jun Zhang, Bin He, Jun Cao

期刊: ADVANCED FUNCTIONAL MATERIALS | 发表时间: 2025-03-20 | DOI: 10.1002/adfm.202420553 | 影响因子: 19.0

研究领域: 肿瘤学, 生物材料科学, 医学工程, 药理学

Disruption of the eEF1A1/ARID3A/PKC-δ Complex by Neferine Inhibits Macrophage Glycolytic Reprogramming in Atherosclerosis

Baoping Xie, Li-Wen Tian, Chenxu Liu, Jiahua Li, Xiaoyu Tian, Rong Zhang, Fan Zhang, Zhongqiu Liu, Yuanyuan Cheng

期刊: Advanced Science | 发表时间: 2025-02-20 | DOI: 10.1002/advs.202416158 | 影响因子: 14.1

研究领域: 心血管疾病, 免疫学, 药理学, 分子生物学

Design and synthesis of novel sulfur-substituted triptolide with the ability to induce autophagy through inhibition of SRSF1 expression

Xinyi Chen, Jichen Guan, Yuzhi Lin, Haowen Luo, Junyi Liu, Jie Ma, Chuangjun Li, Dongming Zhang, Yingda Zang, Fangfang Lai

期刊: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 发表时间: 2025-02-02 | DOI: 10.1016/j.ejmech.2025.117342 | 影响因子: 5.9

研究领域: 药理学, 肿瘤学, 分子生物学