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Disruption of the eEF1A1/ARID3A/PKC-δ Complex by Neferine Inhibits Macrophage Glycolytic Reprogramming in Atherosclerosis

Baoping Xie, Li-Wen Tian, Chenxu Liu, Jiahua Li, Xiaoyu Tian, Rong Zhang, Fan Zhang, Zhongqiu Liu, Yuanyuan Cheng

期刊: Advanced Science | 发表时间: 2025-02-20 | DOI: 10.1002/advs.202416158 | 影响因子: 14.3

研究领域: 心血管疾病, 免疫学, 药理学, 分子生物学

Design and synthesis of novel sulfur-substituted triptolide with the ability to induce autophagy through inhibition of SRSF1 expression

Xinyi Chen, Jichen Guan, Yuzhi Lin, Haowen Luo, Junyi Liu, Jie Ma, Chuangjun Li, Dongming Zhang, Yingda Zang, Fangfang Lai

期刊: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 发表时间: 2025-02-02 | DOI: 10.1016/j.ejmech.2025.117342 | 影响因子: 6.0

研究领域: 药理学, 肿瘤学, 分子生物学

The CCL5/CCR5/SHP2 axis sustains Stat1 phosphorylation and activates NF-κB signaling promoting M1 macrophage polarization and exacerbating chronic prostatic inflammation

Jin Chen, Zhang Fei, Luo Hailang, Li Boyang, Jiang Xue, Pirozzi Christopher J., Liang Chaozhao, Zhang Meng

期刊: Cell Communication and Signaling | 发表时间: 2024-12-05 | DOI: 10.1186/s12964-024-01943-w | 影响因子: 8.2

研究领域: 免疫学, 炎症研究, 泌尿科, 药理学, 细胞生物学

Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation

Chen Yifan, Xian Miao, Ying Wenwen, Liu Jiayi, Bing Shaowei, Wang Xiaomin, Yu Jiayi, Xu Xiaojun, Xiang Senfeng, Shao Xuejing, Cao Ji, He Qiaojun, Yang Bo, Ying Meidan

期刊: Nature Communications | 发表时间: 2024-11-13 | DOI: 10.1038/s41467-024-53398-9 | 影响因子: 14.7

研究领域: 肿瘤学, 血液学, 代谢, 药理学

Quercetin Protects against Silicon dioxide Particles-induced spleen ZBP1-Mediated PANoptosis by regulating the Nrf2/Drp1/mtDNA axis

Ke Li, Xuejiao Yang, Tong Xu, Xu Shi, Shiwen Xu

期刊: INTERNATIONAL IMMUNOPHARMACOLOGY | 发表时间: 2024-11-02 | DOI: 10.1016/j.intimp.2024.113546 | 影响因子: 4.8

研究领域: 毒理学, 免疫学, 细胞生物学, 药理学

Intranasal administration of Clostridium butyricum and its derived extracellular vesicles alleviate LPS-induced acute lung injury

Li Liu, Cihua Zheng, Zhenyang Xu, Zhuoya Wang, Yuchun Zhong, Zhidong He, Wenming Zhang, Yuanbing Zhang

期刊: Microbiology Spectrum | 发表时间: 2024-10-29 | DOI: 10.1128/spectrum.02108-24 | 影响因子: 3.7

研究领域: 微生物学, 免疫学, 呼吸病学, 药理学

Combined targeting of GPX4 and BCR-ABL tyrosine kinase selectively compromises BCR-ABL+ leukemia stem cells

Zeng Chengwu, Nie Dingrui, Wang Xianfeng, Zhong Shuxin, Zeng Xiangbo, Liu Xin, Qiu Kangjie, Peng Xueting, Zhang Wenyi, Chen Shengting, Zha Xianfeng, Chen Cunte, Chen Zhenhua, Wang Weizhang, Li Yangqiu

期刊: Molecular Cancer | 发表时间: 2024-10-28 | DOI: 10.1186/s12943-024-02162-0 | 影响因子: 27.7

研究领域: 肿瘤学, 血液学, 药理学

The inhibition effect of psoralen on prostate cancer PC3 cells via down-regulation of long non-coding RNA ENST00000510619

Shushang Chen, Mingfang Weng, Ronghui Lin, Junjie Wei, Lingfeng Zhu, Zhenghua Ju, Zhitao Lin, Bin Zhan, Ram A Pathak, Rashid K Sayyid, Rong Ge

期刊: Translational Andrology and Urology | 发表时间: 2024-10-28 | DOI: 10.21037/tau-24-457 | 影响因子: 1.9

研究领域: 肿瘤学, 分子生物学, 药理学, 细胞生物学, 基因组学

Fasting-mimicking diet potentiates anti-tumor effects of CDK4/6 inhibitors against breast cancer by suppressing NRAS- and IGF1-mediated mTORC1 signaling

Ning Li, Ya-Jie Sun, Li-Yun Huang, Rong-Rong Li, Jun-Sheng Zhang, Ai-Hua Qiu, Jing Wang, Lu Yang

期刊: DRUG RESISTANCE UPDATES | 发表时间: 2024-10-21 | DOI: 10.1016/j.drup.2024.101161 | 影响因子: 15.8

研究领域: 肿瘤学, 分子生物学, 药理学, 癌症治疗

A cofactor-induced repressive type of transcription factor condensation can be induced by synthetic peptides to suppress tumorigenesis

TangYang , ChenFan , FangGemin , ZhangHui , ZhangYanni , ZhuHanying , ZhangXinru , HanYi , CaoZhifa , GuoFenghua , WangWenjia , YeDan , JuJunyi , TanLijie , LiChuanchuan , ZhaoYun , ZhouZhaocai , AnLiwei , JiaoShi

期刊: EMBO JOURNAL | 发表时间: 2024-10-02 | DOI: 10.1038/s44318-024-00257-4 | 影响因子: 9.4

研究领域: 分子生物学, 癌症研究, 细胞生物学, 药理学