Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

Jin Zhenming, Du Xiaoyu, Xu Yechun, Deng Yongqiang, Liu Meiqin, Zhao Yao, Zhang Bing, Li Xiaofeng, Zhang Leike, Peng Chao, Duan Yinkai, Yu Jing, Wang Lin, Yang Kailin, Liu Fengjiang, Jiang Rendi, Yang Xinglou, You Tian, Liu Xiaoce, Yang Xiuna, Bai Fang, Liu Hong, Liu Xiang, Guddat Luke W., Xu Wenqing, Xiao Gengfu, Qin Chengfeng, Shi Zhengli, Jiang Hualiang, Rao Zihe, Yang Haitao

期刊: NATURE |  发表时间: 2020-04-09 |  DOI: 10.1038/s41586-020-2223-y |  影响因子: 42.779

研究领域: 病毒学, 药理学, 结构生物学, 药物发现

A human organoid drug screen identifies α2-adrenergic receptor signaling as a therapeutic target for cartilage regeneration

Xiaocui Wei, Jingyang Qiu, Ruijun Lai, Tiantian Wei, Zhijie Lin, Shijiang Huang, Yuanjun Jiang, Zhanpeng Kuang, Hao Zeng, Yan Gong, Xiaoling Xie, Jun Yang, Yue Zhang, Sheng Zhang, Zhipeng Zou, Xuefei Gao, Xiaochun Bai

期刊: Cell Stem Cell |  发表时间: 2024-09-30 |  DOI: 10.1016/j.stem.2024.09.001 |  影响因子: 19.8

研究领域: 干细胞生物学, 再生医学, 药理学, 组织工程

Small-molecule compounds boost genome-editing efficiency of cytosine base editor

Zhao Tianyuan, Li Qing, Zhou Chenchen, Lv Xiujuan, Liu Hongyan, Tu Tianxiang, Tang Na, Cheng Yanbo, Liu Xiaoyu, Liu Changbao, Zhao Junzhao, Song Zongming, Wang Haoyi, Li Jinsong, Gu Feng

期刊: NUCLEIC ACIDS RESEARCH |  发表时间: 2021-07-30 |  DOI: 10.1093/nar/gkab645 |  影响因子: 16.971

研究领域: 遗传学, 分子生物学, 治疗学, 细胞生物学

Structure-based discovery of dual pathway inhibitors for SARS-CoV-2 entry

Wang Haofeng, Yang Qi, Liu Xiaoce, Xu Zili, Shao Maolin, Li Dongxu, Duan Yinkai, Tang Jielin, Yu Xianqiang, Zhang Yumin, Hao Aihua, Wang Yajie, Chen Jie, Zhu Chenghao, Guddat Luke, Chen Hongli, Zhang Leike, Chen Xinwen, Jiang Biao, Sun Lei, Rao Zihe, Yang Haitao

期刊: Nature Communications |  发表时间: 2023-11-21 |  DOI: 10.1038/s41467-023-42527-5 |  影响因子: 16.6

研究领域: 病毒学, 药理学, 分子生物学, 传染病学