Structural basis for FGF hormone signalling

Chen Lingfeng, Fu Lili, Sun Jingchuan, Huang Zhiqiang, Fang Mingzhen, Zinkle Allen, Liu Xin, Lu Junliang, Pan Zixiang, Wang Yang, Liang Guang, Li Xiaokun, Chen Gaozhi, Mohammadi Moosa

期刊: NATURE |  发表时间: 2023-06-07 |  DOI: 10.1038/s41586-023-06155-9 |  影响因子: 64.8

研究领域: 分子生物学, 细胞生物学, 结构生物学, 药理学, 代谢学

Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor

Jinjia Zhang, Junhong Li, Yongqiang Hou, Yao Lin, Hao Zhao, Yiran Shi, Kaiyun Chen, Cheng Nian, Jiayu Tang, Lei Pan, Yunzhi Xing, Huan Gao, Bingying Yang, Zengfang Song, Yao Cheng, Yue Liu, Min Sun, Yueyue Linghu, Jiaxin Li, Haitao Huang, Zhangjian Lai, Zhien Zhou, Zifeng Li, Xiufeng Sun, Qinghua Chen, Dongxue Su, Wengang Li, Zhihai Peng, Pingguo Liu, Wei Chen, Hongling Huang, Yixin Chen, Bailong Xiao, Lilin Ye, Lanfen Chen, Dawang Zhou

期刊: CELL |  发表时间: 2024-05-13 |  DOI: 10.1016/j.cell.2024.04.023 |  影响因子: 45.5

研究领域: 免疫学, 癌症生物学, 细胞生物学, 转录调控

Overcoming multi-drug resistance in SCLC: a synergistic approach with venetoclax and hydroxychloroquine targeting the lncRNA LYPLAL1-DT/BCL2/BECN1 pathway

Li Shuxin, Lv Jianyi, Li Zhihui, Zhang Qiuyu, Lu Jing, Huo Xueyun, Guo Meng, Liu Xin, Li Changlong, Wang Jinghui, Shi Hanping, Deng Li, Chen Zhenwen, Du Xiaoyan

期刊: Molecular Cancer |  发表时间: 2024-10-31 |  DOI: 10.1186/s12943-024-02145-1 |  影响因子: 27.7

研究领域: 肿瘤学, 分子生物学, 药理学, 细胞生物学

Sphingosine kinase 1 promotes tumor immune evasion by regulating the MTA3-PD-L1 axis

Lau Poyee, Zhang Guanxiong, Zhao Shuang, Liang Long, Zhang Hailun, Zhou Guowei, Hung Mien-Chie, Chen Xiang, Liu Hong

期刊: Cellular & Molecular Immunology |  发表时间: 2022-09-01 |  DOI: 10.1038/s41423-022-00911-z |  影响因子: 22.096

研究领域: 肿瘤学, 免疫学, 癌症生物学, 药理学

Initial cardioplegic flush with crystalloid cardioplegia improves donor heart preservation and function via NR4A3 upregulation and metabolic reprogramming

Yixuan Wang, Zihao Wang, Chen Dong, Wai Yen Yim, Zongtao Liu, Jincheng Hou, Chenghao Li, Shuyu Wen, Yongbu Peng, Qiutang Zeng, Jiawei Shi, Fayuan Liu, Weihua Qiao, Fei Li, Nianguo Dong

期刊: Science Bulletin |  发表时间: 2025-03-10 |  DOI: 10.1016/j.scib.2025.03.019 |  影响因子: 21.1

研究领域: 心脏病学, 移植医学, 分子生物学

Integrated Microfluidic Hydrogel-Enhanced Microwell Array for Uniform Self-Assembly, Long-Term Culture, and Neural Differentiation of Mesenchymal Stem Cell Spheroids

Wangyu Bi, Shanglin Cai, Liping Zhou, Jinglei Zheng, Yanxin Cui, Yingxian Li, Shuting Liu, Hongyu Chen, Shuang Sha, Jiaxin Li, Qiansu Ma, Zhaoshi Bao, Cencan Xing, Hongwu Du, Lei Wang

期刊: ADVANCED FUNCTIONAL MATERIALS |  发表时间: 2025-05-12 |  DOI: 10.1002/adfm.202501265 |  影响因子: 19.0

研究领域: 再生医学, 干细胞研究, 神经科学, 生物工程

Honeysuckle-Derived Carbon Dots With Robust Catalytic and Pharmacological Activities for Mitigating Lung Inflammation by Inhibition of Caspase11/GSDMD-Dependent Pyroptosis

Zhichao Deng, Yujie Zhang, Runqing Li, Yuanyuan Zhu, Chenxi Xu, Bowen Gao, Wenlong Wang, Chenguang Ding, Bin He, Xingzhuo Zhu, Mei Yang, Ting Liang, Mingzhen Zhang

期刊: ADVANCED FUNCTIONAL MATERIALS |  发表时间: 2025-01-23 |  DOI: 10.1002/adfm.202418683 |  影响因子: 19.0

研究领域: 生物医学工程, 药理学, 分子生物学, 炎症研究, 纳米技术

A Functional 3D Biomimetic Osteon Accelerates Bone Regeneration

Chenxu Zhu, Zexi Li, Xubin Qiu, Baizhen Zhao, Huan Wang, Lijie Wang, Ming Zhuang, Jinbo Liu, Fengxuan Han, Bin Li

期刊: ADVANCED FUNCTIONAL MATERIALS |  发表时间: 2025-03-26 |  DOI: 10.1002/adfm.202500603 |  影响因子: 19.0

研究领域: 组织工程, 再生医学, 生物材料科学, 生物医学工程

A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation

Wu Jianfeng, Yang Kang, Cai Shaowei, Zhang Xiaohan, Hu Lichen, Lin Fanjia, Wu Su-qin, Xiao Changchun, Liu Wen-Hsien, Han Jiahuai

期刊: Nature Communications |  发表时间: 2022-11-28 |  DOI: 10.1038/s41467-022-34969-0 |  影响因子: 17.694

研究领域: 免疫学, 细胞生物学, 分子生物学

D-mannose alleviates intervertebral disc degeneration through glutamine metabolism

Dong Zheng-Lin, Jiao Xin, Wang Zeng-Guang, Yuan Kai, Yang Yi-Qi, Wang Yao, Li Yun-Tao, Wang Tian-Chang, Kan Tian-You, Wang Jian, Tao Hai-Rong

期刊: Military Medical Research |  发表时间: 2024-05-06 |  DOI: 10.1186/s40779-024-00529-4 |  影响因子: 16.7

研究领域: 骨科, 分子生物学, 代谢组学, 转录组学, 药理学